Process for preparing extra pure 2, 6-diisopropyl

专利名称：Process for preparing extra pure 2, 6-diisopropyl phenol

发明人：Kirti Prakash Jain,Dhananjay Uddhavrao

Edaki,Harpreet Singh Minhas,Gurpreet SinghMinhas

申请号：US13578456申请日：20100810公开号：US0852B2公开日：20140304

摘要：Disclosed herein is a process for the preparation of highly pure 2,6-diisopropylphenol (Formula I), which comprises reacting p-hydroxy benzoic acid (Formula II) with analkylating agent in presence of aq. mineral acid followed by basification and subsequentwashings to yield 4-hydroxy-3,5-diisopropylbenzoic acid (Formula III) free of dimerimpurity, 4,4′-oxydibenzoic acid of Formula IV, ether impurity 3,5-di(propan-2-yl)-4-(propan-2-yloxy)benzoic acid of Formula V and the monoalkylated impurity 4-hydroxy-3-(propan-2-yl)benzoic acid of Formula VI; and decarboxylating 4-hydroxy-3,5-diisopropylbenzoic acid (Formula III) in presence of high boiling solvent and sodiumhydroxide as a catalyst at high temperature to yield 2,6-diisopropyl phenol substantiallyfree of ether impurity 1,3-di(propan-2-yl)-2-(propan-2-yloxy)benzene of Formula VII andmonoalkylated phenol impurity 2-(propan-2-yl) phenol of Formula VIII. Propofolprepared by the process of the present invention is suitable for pharmaceutical use.

申请人：Kirti Prakash Jain,Dhananjay Uddhavrao Edaki,Harpreet Singh Minhas,GurpreetSingh Minhas

地址：Udaipur IN,Aurangabad IN,Mumbai IN,Mumbai IN

国籍：IN,IN,IN,IN

代理机构：Kramer Amado, P.C.

更多信息请下载全文后查看